MATTERS ARISING: A case of progressive encephalomyelitis with rigidity and positive antiglutamic acid dehydrogenase antibodies
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چکیده
منابع مشابه
Progressive encephalomyelitis with rigidity and myoclonus: the first pediatric case with glycine receptor antibodies.
IMPORTANCE Progressive encephalomyelitis with rigidity and myoclonus is characterized by rigidity, painful muscle spasms, hyperekplexia, and brainstem signs. Recently, glycine receptor alpha 1 antibodies have been described in adult patients with progressive encephalomyelitis with rigidity and myoclonus. We describe a pediatric case. OBSERVATIONS A 14-month-old child developed startle-induced...
متن کامل[A case of progressive encephalomyelitis with rigidity and myoclonus associated with anti-GAD, anti-glycine receptor and anti-GM1 antibodies].
A 62-year-old woman with one-year history of type 1 diabetes mellitus was admitted to our hospital with progressive weakness in the lower extremities and urinary dysfunction following high fever. On admission, she had rigidity and myoclonus in the upper extremities with sensory ataxia. Cerebrospinal fluid examination revealed mild pleocytosis and oligoclonal band. Glutamic acid decarboxylase (G...
متن کاملProgressive encephalomyelitis with rigidity and myoclonus: a new variant with DPPX antibodies.
OBJECTIVE To describe a novel and distinct variant of progressive encephalomyelitis with rigidity and myoclonus (PERM) associated with antibodies directed against dipeptidyl peptidase-like protein 6 (DPPX), a regulatory subunit of the Kv4.2 potassium channels on the surface of neurons. METHODS Case series describing the clinical, paraclinical, and serologic features of 3 patients with PERM. A...
متن کاملProgressive Encephalomyelitis with Rigidity and Myoclonus Associated With Anti-GlyR Antibodies and Hodgkin’s Lymphoma: A Case Report
INTRODUCTION A 60-year-old man presented with a 6-month history of low back pain and progressive rigidity of the trunk and lower limbs, followed by pruritus, dysphonia, hyperhydrosis, and urinary retention. Brain and spinal imaging were normal. EMG showed involuntary motor unit hyperactivity. Onconeural, antiglutamic acid decarboxylase (anti-GAD), voltage-gated potassium channel, and dipeptidyl...
متن کاملProgressive encephalomyelitis with rigidity and myoclonus: glycine and NMDA receptor antibodies.
BACKGROUND The syndrome of progressive encephalopathy with limb rigidity has been historically termed progressive encephalomyelitis with rigidity and myoclonus (PERM) or stiff-person syndrome plus. METHODS The case is presented of a previously healthy 28-year-old man with a rapidly fatal form of PERM developing over 2 months. RESULTS Serum antibodies to both NMDA receptors (NMDAR) and glyci...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1991
ISSN: 0022-3050
DOI: 10.1136/jnnp.54.11.1032-e